The painting is very expressive. I like the way the woman is twisted and the way she turns her head away from the ceiling. It also suggests a claustrophobic reaction. The position of the legs, that of the hands and the red eyes enhance the feeling of fear, which the whole painting speaks of.
I also like the symbols of the lock and the key. I see this as a message like: The key to her freedom is at her, but she cannot open the lock. Also, the door which leads to freedom is unlocked, yet she cannot see it. So, she remains a prisoner of her fears.
The color choice is good as red is a color associated with fear and danger. I also like the exagerated size of the character as it's in contrast with the motive of her fears.
This is really a combination of a lot of fears. Fear of spiders, claustrophobia, fear of the dark, fear of clowns (?). Each one of those is very well presented in the piece.
This showcases the abilities of the artist. The lighting, perspective and facial features are extremely well done. The locket around her wrist and key around her neck symbolize that fear is really self-implicated. You are your own salvation. That was very clever to put.
The only thing I find a bit off are the panties. I think it's their colorfulness, it doesn't seem to fit. But that might just be my opinion. You might've put that on purpose for contrast.
All in all, a great piece with immense impact and symbolism.